Semisynthetic Coumermycins: Structure-Activity Relationships

Structure-activity relationships among 4"-(p-substituted phenylacetyl)-deltamycins, the semisynthetic macrolides.

Concerning relationships between electronegativity and antimicrobial activity, studies on chloramphenicol derivatives were reported in 19562). Antimicrobial activity of PAD derivatives (Table 1) was estimated from the relative electronegativity of the substituents in the chloramphenicol studies (Note 1) but there was no linear relationship between them. Many studies have recently shown that che...

Structure-radical scavenging activity relationships of hydroxytoluene derivatives

Research works proposed that radical scavenging activity of flavonoids is due to ring B, andthe remaining part of the molecule can be disregarded. Thus the objective of this work is toobserve whether hydroxytoluenes account the radical scavenging activity of flavonoid and toestablish structural requirements for their activity (as they showed appreciable activity) andelucidate a comprehensive me...

QnrS1 structure-activity relationships.

OBJECTIVES Loop B is important for low-level quinolone resistance conferred by Qnr proteins. The role of individual amino acids within QnrS1 loop B in quinolone resistance and gyrase protection was assessed. METHODS qnrS1 and 11 qnrS1 alleles with site-directed Ala mutations in loop B were expressed in Escherichia coli BL21(DE3) and proteins were purified by affinity chromatography. Ciproflox...

Structure-activity relationships of saframycins.

In vitro antitumor activities of 13 saframycins, including the potent antitumor component, saframycin A, were determined with the highly sensitive established cell line of L1210 mouse leukemia to investigate structure-activity relationships. Saframycins which lack the alpha-cyanoamine group or the alpha-carbinolamine group exhibited much lower cytotoxic activity than saframycin A. The modificat...

Structure-activity relationships in cannabinoids.